Apoptosis Reagents and Kits
Cayman Chemical Stm Cel Smal Molcule Scre 50uL
An Asc-1 inhibitor selectively inhibits Asc-1 in HEK293 cells expressing Asc-1 (IC50 36.8 nM) over 40 other transporters (IC50s >10 UM) inhibits serine cysteine glycine and alanine import and cAMP-induced increases in the OCR and decreases UCP1 levels in primary human white and brown adipose cells at 100 nM decreases the number of malformed neurons and reduces contextual fear memory deficits in a mouse model of surgery-induced brain damage when intracerebroventricularly infused
Cayman Chemical DmyoInosItol phsphat Scre 50uL
An inhibitor of wild-type and mutant EGFR (IC50s 1.07 0.46 0.13 0.26 and 0.19 nM for wild-type EGFR EGFRd746-750/T790M/C797S EGFRL858R/T790M/C797S EGFRd746-750/T790M and EGFRL858R/T790M respectively) inhibits the proliferation of wild-type EGFR-expressing A431 EGFRd746-750/T790M/C797S-expressing Ba/F3 EGFRd746-750/T790M/C797S-expressing H1975 and EGFRd746-750-expressing PC-9 cells (IC50s 147 26.8 163 and 45 nM respectively) reduces tumor growth in triple mutant EGFR mouse xenograft models
Revvity Health Sciences Inc Cellaca PLX, Annexin V-FITC/PI Apoptosis Kit, 100 Tests
Cellaca PLX, Annexin V-FITC/PI Apoptosis Kit, 100 Tests
Cayman Chemical Z-YVAD-CMKtrIfluoroacetate 1mg
An internal standard for the quantification of lauroyl-L-carnitine by GC- or LC-MS
Cayman Chemical Hoechst 33258 50mg
A chemiluminescent substrate of firefly luciferase which produces light upon oxidative decarboxylation in the presence of ATP
Cayman Chemical Caspase-3 InhIbItr VII 1mg
Human SIRT1 is the homolog of yeast Sir2 and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis Cayman s SIRT1 FRET-based Screening Assay provides a convenient fluorescence-based method for screening SIRT1 inhibitors or activators The procedure requires only two easy steps both performed in the same microplate In the first step the substrate which is coupled to the fluorophore and quencher is incubated with human recombinant SIRT1 along with its cosubstrate NAD Deacetylation sensitizes the substrate such that treatment with the developer in the second step results in the separation of the quencher and fluorophore The resulting fluorescence is analyzed using an excitation wavelength between 335-345 nm and emission wavelength between 440-465 nm
Cayman Chemical Caspase-3 InhIbItr VII 10mg
A bacterial quorum sensing signal molecule promotes the expression of the transcriptional activator TraR in the gram-negative bacterium A tumefaciens
Cayman Chemical Hoechst 33342hydrochlorIde 2mL
A guanidine-modified biotin derivative and an inhibitor of iNOS and nNOS (Kis 21.8 and 37.5 UM for the mouse and rat enzymes respectively) prevents hypoxia-ischemia-induced decreases in brain phosphocreatine and ATP levels and increases in edema in the parietal cortex and striatum as well as reduces apoptosis in the parietal- and temporal cortex and striatum in piglets at 0.2 mg/kg every four hours increases survival of and decreases electrographic seizures in hypoxia-ischemia-injured piglets at 0.2 and 1 mg/kg every four hours LNPs containing 2-iminobiotin conjugated to poly-L-lysine have been used to improve LNP tumor targeting uptake and retention compared with LNPs containing biotin conjugated to poly-L-lysine in rats
Cayman Chemical ANTIBODY Z-FF-FMK 10mg
A PI3Ka inhibitor (Ki 0.034 nM) selective for PI3Ka over PI3KB PI3K and PI3KY (Kis 99.7 12.2 and 18.2 nM respectively) and is 4.4-fold selective in decreasing the phosphorylated levels of PRAS40 in HCC1954 cells which express wild-type p110a and p110aH1047R over HDQ-P1 cells which only express wild-type p110a induces PARP cleavage a marker of apoptosis in HCC1954 cells at 111 nM reduces the levels of phosphorylated Akt and PRAS40 and the levels of mutant p110a in HCC1954 cells but not HDQ-P1 cells at 111 333 and 1000 nM decreases tumor volume in an HCC1954 mouse xenograft model at 25 or 50 mg/kg per day
Cayman Chemical ANTIBODY Z-FF-FMK 5mg
An antimicrobial peptide active against E. coli and S. aureus (IC50s 730 and 210 UM respectively) induces hemolysis of isolated ovine erythrocytes
Cayman Chemical Z-VAD OMe-FMK 5mg
An analytical reference standard categorized as a quinazolone intended for research and forensic applications